Argonne Chemistry Staff

Lisa M. Utschig

Photosynthesis Group
Argonne National Laboratory
Chemistry Division, E109
9700 South Cass Avenue
Argonne, IL 60439
Phone: 630-252-3544
Fax: 630-252-9289
E-mail: utschig@anl.gov

Education

Ph.D., Inorganic Chemistry, Northwestern University,
Evanston, IL - June 1995

M.S. (non-thesis), Inorganic Chemistry, Northwestern University,
Evanston, IL - December 1991

B.A., Chemistry, (Magna Cum Laude), Cornell College,
Mt. Vernon, IA - May 1990

Honors and Activities

Argonne Pacesetter Award, 2007
Enrico Fermi Scholar, 1995 - 1997
NIH National Research Service Award Training Grant
in Molecular Biophysics, 1992-1994
Phi Lamba Upsilon, 1991-Present
National Science Foundation Honorable Mention, 1991
Departmental Fellowship, 1990-Present
Phi Beta Kappa, Elected Member 1990
The American Institute of Chemists Foundation
Student Award, 1990
ACS Analytical Chemistry Student Award, 1989
Arthur E. Lowell Scholarship for Leadership and
Academic Excellence, 1988-1990
CRC Outstanding Freshman Chemistry Award, 1987
William Fletcher King Scholarship for Academic
Potential, 1986-1990
Graduated Salutatorian, 1986

Research Experience

2003-present  Chemist, Chemistry Division, Argonne National Laboratory
1998-2002      Assistant Scientist, Chemistry Division, Argonne National Laboratory
1995-1997      Enrico Fermi Scholar, Chemistry Division, Argonne National Laboratory 1990-1995      Ph.D. Thesis Research, Northwestern University, Evanston, IL
                        Thesis title: "Heavy Metal Recognition by the MerR Metalloregulatory
                        Protein and Mercury-199 NMR Methods as Spectroscopic Probes of                         Metalloproteins."         Advisor: Professor Thomas V. O'Halloran
1989-1990      Summer Undergraduate Research Fellowship (SURF), University of
                        Iowa, Iowa City, IA

Teaching Experience

Visiting Lecturer, Cornell College, Mt. Vernon, IA
General Chemistry, One-Course-at-a-Time curriculum, Nov. 1994
Teaching Assistant, Northwestern University, Evanston, IL
General Chemistry Laboratory, 1989-1990
Physical Chemistry Advanced Spectroscopy Lab, 1992-1994

Publications

Magnetic Resonance Spectroscopy, Calcium Content, and Anion
Coordination Studies of Bovine and Goat Lactoperoxidase, G. S. Lukat,
M. B. Doran, L. M. Utschig and H. M. Goff, J. Inorg. Biochem. 1993,
50, 157.
Biochemical and Spectroscopic Probes of Hg(II) Coordination
Environments in Proteins, L. M. Utschig, J. G. Wright and T. V. O'Halloran,
In Methods in Enzymology, edited by B. Vallee and J. Riordan, Academic
Press: San Diego, 1993; Vol. 226; pp 71-97.
Structural Characterization of the Binding-Site in the MerR
Metalloregulatory Protein, K. Clark, L. Utschig, T. V. O'Halloran and
J. E. Penner-Hahn, Japanese J. Appl. Physics, 1993, 32, 536.
The ¹⁹⁹Hg Chemical Shift as a Probe of Coordination Environments
in Blue Copper Proteins, L. M. Utschig, J. G. Wright, G. Dieckmann,
V. Pecoraro and T. V. O'Halloran, Inorg. Chem. 1995, 34, 2497-2498.
Mercury-¹⁹⁹NMR of the Metal Receptor Site in MerR and its Protein-
DNA Complex, L. M. Utschig, J. W. Bryson and T. V. O'Halloran,
Science, 1995, 268, 380-385.
Probing Copper-Thioether Coordination Chemistry in Rusticyanin and
Azurin by 2D ¹H-¹⁹⁹Hg NMR, L. M. Utschig, T. Baynard,
C. Strong and T. V. O'Halloran, Inorg. Chem, 1997, 36, 2926-2927.
Mercury-Responsive Gene Regulation and Mercury-199 as a Probe
of Protein Structures, D. L Huffman, L. M Utschig and T. V. O'Halloran,
in Metal Ions in Biological Systems, edited by A. Sigel and H. Sigel,
Marcel Dekker: New York, 1997, Vol. 34.
The De Novo Design of Mercury-Binding Two- and Three-Helical
Bundles, G. R. Dieckmann, D. L. Tierney, L. M. Utschig, D. K. McRorie,
T. V. O'Halloran, J. E. Penner-Hahn, W. F. DeGrado and V. L. Pecoraro,
JACS, 1997, 119, 6195-6196.
Influence of Iron-Removal Procedures on Sequential Electron
Transfer in Photosynthetic Bacterial Reaction Centers Studied by
Transient EPR Spectroscopy, L. M. Utschig, S. R. Greenfield, J. Tang,
P. D. Laible and M. C. Thurnauer, Biochem., 1997, 36, 8548-8558.
Discovery of a New Metal-Binding Site in Photosynthetic Bacterial
Reaction Centers that Modulates Q_A to Q_B Electron Transfer,
L. M. Utschig, Y. Ohigashi, M. C. Thurnauer and D. M. Tiede,
Biochem., 1998, 37, 8278-8281.
Paramagnetic Rh(III) Complexes from Reactions of Phosphines
with Hydride-Bridged and Nonbridged Rhodium Phthalocyanine
Dimers: Metal-to-Ligand Charge Transfer Induced by Phosphines,
M. J. Chen, L. M. Utschig, and J. W. Rathke, Inorg. Chem., 1998,
37, 5786-5792.
Resolution of Electron and Proton Transfer Events in the
Electrochromism Associated with Quinone Reduction in Bacterial
Reaction Centers, D. M. Tiede, L. Utschig, D. K. Hanson and
D. M. Gallo, Photosynthesis Research, 1998, 55, 267-273.
A New Metal-Binding Site in Photosynthetic Bacterial Reaction
Centers that Modulates Q_A to Q_B Electron Transfer, L. M. Utschig,
Y. Ohigashi, M. C. Thurnauer and D. M. Tiede, Biochem., 1998,
37, 8278-8281.
Transient W-Band EPR Study of Sequential Electron Transfer in
Photosynthetic Bacterial Reaction Centers, J. Tang, L. M. Utschig,
O. Poluektov and M. C. Thurnauer, J. Phys. Chem. B, 1999,
103, 5145-5150.
Magnetic Field Induced Orientation of Photosynthetic Reaction
Centers as Revealed by Time-Resolved W-Band EPR of Spin-
Correlated Radical Pairs, T. Berthold, M. Bechtold, U. Heinen,
G. Link, O. Poluektov, L. Utschig, J. Tang, M. C. Thurnauer and
G. Kothe, J. Phys. Chem. B, 1999, 103, 10733-10736.
EPR Investigation of Cu²⁺-Substituted Photosynthetic Bacterial
Reaction Centers: Evidence for Histidine Ligation at the Surface Metal
Site, L. M. Utschig, O. Poluektov, D. M. Tiede and M. C. Thurnauer,
Biochem., 2000, 39, 2961-2969.
High-Frequency Approach to the Electron Spin-Polarization
Effects Observed in the Photosynthetic Reaction Centers,
O. G. Poluektov, L. M. Utschig, J. Tang, A. A. Dubinski,
S. Schlesselman, and M. C. Thurnauer, Appl. Magn. Reson.,
2001, 21, 311-323.
Cu²⁺ Site in Photosynthetic Bacterial Reaction Centers from Rhodobacter
sphaeroides, Rhodobacter capsulatus, and Rhodopseudomonas viridis,
L. M. Utschig, O. Poluektov, S. Schlesselman, M. C. Thurnauer and
D. M. Tiede, Biochem., 2001, 40, 6132-6141.
Structure of the P⁺₇₀₀A^-₁ Radical Pair Intermediate in Photosystem I
by High Time Resolution Multifrequency Electron Paramagnetic
Resonance: Analysis of Quantum Beat Oscillations, G. Link,
T. Berthold, M. Bechtold, J-U. Weidner, E. Ohmes, J. Tang,
O. Poluektov, L. Utschig, S. Schlesselman, M. C. Thurnauer and
G. Kothe, J. Am. Chem. Soc., 2001, 123, 4211-4222.
Electronic Structure of the P₇₀₀ Special Pair from High-Frequency
Electron Paramagnetic Resonance Spectroscopy, O. G. Poluektov,
L. M. Utschig, S. L. Schlesselman, K. V. Lakshmi, G. W. Brudvig,
G. Kothe, and M. C. Thurnauer, J. Phys. Chem. B, 2002, 106 (35),
8911-8916.
Probing Local Dynamics of the Photosynthetic Bacterial Reaction
Center with a Cysteine Specific Spin Label, O. G. Poluektov,
L. M. Utschig, S. Dalosto, and M. C. Thurnauer, J. Phys. Chem. B
2003, 107 (25), 6239-6244.
ENDOR of Spin-Correlated Radical Pairs in Photosynthesis at High
Magnetic Field: A Tool for Mapping Electron Transfer Pathways,
O. G. Poluektov, L. M. Utschig, A. A. Dubinskij, and M. C. Thurnauer
J. Am. Chem. Soc. Comm., 2004, 126 (6), 1644-1645.
Pulsed EPR/ENDOR Characterization of the Cu²⁺ Surface Site in
Photosynthetic Bacterial Reaction Centers, L. M. Utschig,
A. V. Astashkin, A. M. Raitsimring, M. C. Thurnauer, and
O. G. Poleuktov, J. Phys. Chem. B, 2004, 108, 11150-11156.
Metal Ion Modulated Electron Transfer in Photosynthetic Proteins,
Acc. Chem. Res., 2004, 37, 439-447.
Electron Transfer Pathways and Protein Response to Charge
Separation in Photosynthetic Reaction Centers: Time-Resolved
High-Field ENDOR of the Spin-Correlated Radical Pair P₈₆₅⁺Q_A^-,
O. G. Poluektov, L. M. Utschig, A. A. Dubinskij, and M. C. Thurnauer,
J. Am. Chem. Soc., 2005, 127 (11), 4049-4059.
Bidirectional Electron Transfer in Photosystem I: Direct Evidence
from High-Frequency time-Resolved EPR, O. G. Poluektov,
S. V. Paschenko, L. M. Utschig, K. V. Lakshmi, and M. C. Thurnauer,
J. Amer. Chem. Soc., 2005, 127 (34), 11910-11911.
Structural Organization in Photosynthetic Proteins as Studied by
High-Field EPR of Spin-Correlated Radical Pair States, G. Link,
O. G. Poluektov, L. M. Utschig, J. Lalevee, T. Yago, J-U. Weidner,
M. C. Thurnauer, and G. Kothe, Magn. Res. in Chem., 2005, 43,
S103-S109.
Low Temperature Interquinone Electron Transfer in Photosynthetic
Reaction Centers from Rb. sphaeroides and Blc. viridis: Characterization
of Q_B^- States by High-Frequency EPR and ENDOR, L. M. Utschig,
M. C. Thurnauer, D. Tiede, and O. G. Poluektov, Biochemistry, 2005,
44 (43), 14131-14142.
Spin-Correlated Radical Pairs: Differential Effects in High-Field ENDOR
Spectra, A. A. Dubinskij, L. M. Utschig, and O. G. Poluektov, Appl.
Magn. Reson., 2006, 30, 269-286.
Exploring Hyperfine Interactions in Spin-Correlated Radical Pairs
from Photosynthetic Proteins: High-Frequency ENDOR and Quantum
Beat Oscillations, O. G. Poluektov, L. M. Utschig, M. C. Thurnauer,
and G. Kothe, Appl. Magn. Reson., 2007, 31 (1-2), 123-143.
Structure of the Charge Separated State P⁺₈₆₅Q^-_A in the Photosynthetic
Reaction Centers of Rhodobacter sphaeroides by Quantum Beat Oscillations
and High-Field Electron Paramagnetic Resonance: Evidence for Light-Induced
Q^-_A Reorientation, U. Heinen, L. M. Utschig, O. G. Poluektov, G. Link,
E. Ohmes, and G. Kothe, J. Am. Chem. Soc., 2007, 129, 15935-15946.
Protein Environments and Electron Transfer Processes Probed with
High-Frequency ENDOR, O. G. Poluektov and L. M. Utschig, in The
Purple Photosynthetic Bacteria, C. N. Hunter, F. Daldal,
M. C. Thurnauer, and J. T. Beatty, Eds., Kluwer Publishers, In press 2008

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